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The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc
Expression of the c-Myc proto-oncoprotein is tightly regulated in normal cells. Phosphorylation at two conserved residues, threonine58 (T58) and serine62 (S62), regulates c-Myc protein stability. In cancer cells, c-Myc can become aberrantly stabilized associated with altered T58 and S62 phosphorylat...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2657573/ https://ncbi.nlm.nih.gov/pubmed/19131971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.279 |
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