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A transcriptionally silent RXRα supports early embryonic morphogenesis and heart development

Retinoic acid (RA) receptors (RARs) α, β, and γ heterodimerized with rexinoid receptors (RXRs) α, β, and γ mediate the RA signal. To analyze the contribution of the transcriptional activity of RXRα, the main RXR during embryogenesis, we have engineered a mouse line harboring a transcriptionally sile...

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Hlavní autoři: Mascrez, Bénédicte, Ghyselinck, Norbert B., Chambon, Pierre, Mark, Manuel
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2657455/
https://ncbi.nlm.nih.gov/pubmed/19255444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813143106
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