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Efalizumab binding to the LFA-1 α(L) I domain blocks ICAM-1 binding via steric hindrance
Lymphocyte function-associated antigen 1 (LFA-1) plays important roles in immune cell adhesion, trafficking, and activation and is a therapeutic target for the treatment of multiple autoimmune diseases. Efalizumab is one of the most efficacious antibody drugs for treating psoriasis, a very common sk...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2657446/ https://ncbi.nlm.nih.gov/pubmed/19258452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810844106 |
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