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Crystal structure of human CDK4 in complex with a D-type cyclin
The cyclin D1–cyclin-dependent kinase 4 (CDK4) complex is a key regulator of the transition through the G(1) phase of the cell cycle. Among the cyclin/CDKs, CDK4 and cyclin D1 are the most frequently activated by somatic genetic alterations in multiple tumor types. Thus, aberrant regulation of the C...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2657441/ https://ncbi.nlm.nih.gov/pubmed/19237565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809645106 |
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