Crystal structure of human CDK4 in complex with a D-type cyclin

The cyclin D1–cyclin-dependent kinase 4 (CDK4) complex is a key regulator of the transition through the G(1) phase of the cell cycle. Among the cyclin/CDKs, CDK4 and cyclin D1 are the most frequently activated by somatic genetic alterations in multiple tumor types. Thus, aberrant regulation of the C...

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Bibliographic Details
Main Authors: Day, Philip J., Cleasby, Anne, Tickle, Ian J., O'Reilly, Marc, Coyle, Joe E., Holding, Finn P., McMenamin, Rachel L., Yon, Jeff, Chopra, Rajiv, Lengauer, Christoph, Jhoti, Harren
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2657441/
https://ncbi.nlm.nih.gov/pubmed/19237565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809645106
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