Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine

BACKGROUND: Although the systemic administration of cannabinoids produces antinociception, their chronic use leads to analgesic tolerance as well as cross-tolerance to morphine. These effects are mediated by cannabinoids binding to peripheral, spinal and supraspinal CB1 and CB2 receptors, making it...

詳細記述

保存先:
書誌詳細
主要な著者: Garzón, Javier, de la Torre-Madrid, Elena, Rodríguez-Muñoz, María, Vicente-Sánchez, Ana, Sánchez-Blázquez, Pilar
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2009
主題:
Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2657119/
https://ncbi.nlm.nih.gov/pubmed/19284549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-5-11
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