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Identification of Amino Acids in HIV-1 and Avian Sarcoma Virus Integrase Subsites Required for Specific Recognition of the Long Terminal Repeat Ends

A tetramer model for HIV-1 integrase (IN) with DNA representing 20 bp of the U3 and U5 long terminal repeats (LTR) termini was assembled using structural and biochemical data and molecular dynamics simulations. It predicted amino acid residues on the enzyme surface that can interact with the LTR ter...

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書誌詳細
主要な著者: Chen, Aiping, Weber, Irene T., Harrison, Robert W., Leis, Jonathan
フォーマット: Artigo
言語:Inglês
出版事項: 2005
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656937/
https://ncbi.nlm.nih.gov/pubmed/16298997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M510628200
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