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Hydrophobic Side-Chain Length Determines Activity and Conformational Heterogeneity of a Vancomycin Derivative Bound to the Cell Wall of Staphylococcus aureus
Disaccharide modified glycopeptides with hydrophobic sidechains are active against vancomycin-resistant enterococci and vancomycin-resistant S. aureus. The activity depends on the length of the sidechain. The benzyl sidechain of N-(4-fluorobenzyl)vancomycin (FBV) has the minimal length sufficient fo...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2656501/ https://ncbi.nlm.nih.gov/pubmed/18759499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800838c |
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