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Hydrophobic Side-Chain Length Determines Activity and Conformational Heterogeneity of a Vancomycin Derivative Bound to the Cell Wall of Staphylococcus aureus

Disaccharide modified glycopeptides with hydrophobic sidechains are active against vancomycin-resistant enterococci and vancomycin-resistant S. aureus. The activity depends on the length of the sidechain. The benzyl sidechain of N-(4-fluorobenzyl)vancomycin (FBV) has the minimal length sufficient fo...

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Bibliografiske detaljer
Main Authors: Kim, Sung Joon, Schaefer, Jacob
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656501/
https://ncbi.nlm.nih.gov/pubmed/18759499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800838c
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