Induction of SOX4 by DNA damage is critical for p53 stabilization and function

DNA damage response (DDR) acts as a tumorigenesis barrier, and any defects in the DDR machinery may lead to cancer. SOX4 expression is elevated in many types of tumors; however, its role in DDR is still largely unknown. Here, we show that SOX4, a new DNA damage sensor, is required for the activation...

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Bibliografiska uppgifter
Huvudupphovsmän: Pan, Xin, Zhao, Jie, Zhang, Wei-Na, Li, Hui-Yan, Mu, Rui, Zhou, Tao, Zhang, Hai-Ying, Gong, Wei-Li, Yu, Ming, Man, Jiang-Hong, Zhang, Pei-Jing, Li, Ai-Ling, Zhang, Xue-Min
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2009
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656158/
https://ncbi.nlm.nih.gov/pubmed/19234109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810147106
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