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Induction of SOX4 by DNA damage is critical for p53 stabilization and function
DNA damage response (DDR) acts as a tumorigenesis barrier, and any defects in the DDR machinery may lead to cancer. SOX4 expression is elevated in many types of tumors; however, its role in DDR is still largely unknown. Here, we show that SOX4, a new DNA damage sensor, is required for the activation...
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Главные авторы: | , , , , , , , , , , , , |
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Формат: | Artigo |
Язык: | Inglês |
Опубликовано: |
National Academy of Sciences
2009
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Предметы: | |
Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2656158/ https://ncbi.nlm.nih.gov/pubmed/19234109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810147106 |
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