Modulation of gene expression in U251 glioblastoma cells by binding of mutant p53 R273H to intronic and intergenic sequences

Missense point mutations in the TP53 gene are frequent genetic alterations in human tumor tissue and cell lines derived thereof. Mutant p53 (mutp53) proteins have lost sequence-specific DNA binding, but have retained the ability to interact in a structure-selective manner with non-B DNA and to act a...

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Библиографические подробности
Главные авторы: Brázdová, Marie, Quante, Timo, Tögel, Lars, Walter, Korden, Loscher, Christine, Tichý, Vlastimil, Činčárová, Lenka, Deppert, Wolfgang, Tolstonog, Genrich V.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2009
Предметы:
Gene Regulation, Chromatin and Epigenetics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655687/
https://ncbi.nlm.nih.gov/pubmed/19139068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn1085
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