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Simian Virus 40 Large T Antigen Can Specifically Unwind the Central Palindrome at the Origin of DNA Replication

The hydrophilic channels between helicase domains of simian virus 40 (SV40) large T antigen play a critical role in DNA replication. Previous mutagenesis of residues in the channels identified one class of mutants (class A: D429A, N449S, and N515S) with normal DNA binding and ATPase and helicase act...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wang, Weiping, Simmons, Daniel T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655583/
https://ncbi.nlm.nih.gov/pubmed/19144705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01867-08
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