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Ebola Virus Protein VP35 Impairs the Function of Interferon Regulatory Factor-Activating Kinases IKKɛ and TBK-1

The Ebola virus (EBOV) VP35 protein antagonizes the early antiviral alpha/beta interferon (IFN-α/β) response. We previously demonstrated that VP35 inhibits the virus-induced activation of the IFN-β promoter by blocking the phosphorylation of IFN-regulatory factor 3 (IRF-3), a transcription factor th...

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Detalhes bibliográficos
Main Authors: Prins, Kathleen C., Cárdenas, Washington B., Basler, Christopher F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655579/
https://ncbi.nlm.nih.gov/pubmed/19153231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01875-08
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