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Control of the single channel conductance of K(2P)10.1 (TREK-2) by the amino-terminus: role of alternative translation initiation

TREK-2 expressed in mammalian cells exhibits small (∼52 pS) and large (∼220 pS) unitary conductance levels. Here we tested the role of the N-terminus (69 amino acids long) in the control of the unitary conductance, and role of the alternative translation initiation as a mechanism that produces isofo...

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Detalhes bibliográficos
Main Authors: Simkin, Dina, Cavanaugh, Eric J, Kim, Donghee
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655399/
https://ncbi.nlm.nih.gov/pubmed/18845607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.161927
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