Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines

Replicon plasmids encoding an alphavirus RNA replicase constitute an alternative to conventional DNA plasmids with promise for DNA vaccination in humans. Replicase activity amplifies the levels of transgene mRNA through a copying process involving double-stranded (ds) RNA intermediates, which contri...

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Bibliografiske detaljer
Main Authors: Diebold, Sandra S., Schulz, Oliver, Alexopoulou, Lena, Leitner, Wolfgang W., Flavell, Richard A., Reis e Sousa, Caetano
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655288/
https://ncbi.nlm.nih.gov/pubmed/19052633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2008.164
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