Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines

Replicon plasmids encoding an alphavirus RNA replicase constitute an alternative to conventional DNA plasmids with promise for DNA vaccination in humans. Replicase activity amplifies the levels of transgene mRNA through a copying process involving double-stranded (ds) RNA intermediates, which contri...

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Detalhes bibliográficos
Main Authors: Diebold, Sandra S., Schulz, Oliver, Alexopoulou, Lena, Leitner, Wolfgang W., Flavell, Richard A., Reis e Sousa, Caetano
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655288/
https://ncbi.nlm.nih.gov/pubmed/19052633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2008.164
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