Epstein-Barr Nuclear Antigen 1 modulates replication of oriP-plasmids by impeding replication and transcription fork migration through the family of repeats

BACKGROUND: Epstein-Barr virus is replicated once per cell-cycle, and partitioned equally in latently infected cells. Both these processes require a single viral cis-element, termed oriP, and a single viral protein, EBNA1. EBNA1 binds two clusters of binding sites in oriP, termed the dyad symmetry e...

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Bibliographic Details
Main Authors: Aiyar, Ashok, Aras, Siddhesh, Washington, Amber, Singh, Gyanendra, Luftig, Ronald B
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654434/
https://ncbi.nlm.nih.gov/pubmed/19265546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-6-29
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