Wld(S) protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice

The slow Wallerian degeneration (Wld(S)) protein protects injured axons from degeneration. This unusual chimeric protein fuses a 70–amino acid N-terminal sequence from the Ube4b multiubiquitination factor with the nicotinamide adenine dinucleotide–synthesizing enzyme nicotinamide mononucleotide aden...

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Autores principales: Conforti, Laura, Wilbrey, Anna, Morreale, Giacomo, Janeckova, Lucie, Beirowski, Bogdan, Adalbert, Robert, Mazzola, Francesca, Di Stefano, Michele, Hartley, Robert, Babetto, Elisabetta, Smith, Trevor, Gilley, Jonathan, Billington, Richard A., Genazzani, Armando A., Ribchester, Richard R., Magni, Giulio, Coleman, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654131/
https://ncbi.nlm.nih.gov/pubmed/19237596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200807175
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