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Total Synthesis of (±)-Actinophyllic Acid

[Image: see text] The first total synthesis of (±)-actinophyllic acid (1) is reported. Key steps of this synthesis include an intramolecular oxidative coupling of ketone and malonic ester enolates and an aza-Cope−Mannich rearrangement that assembled the core structure of the natural product’s unique...

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Autors principals: Martin, Connor L., Overman, Larry E., Rohde, Jason M.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2008
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654095/
https://ncbi.nlm.nih.gov/pubmed/18491907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja803158y
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