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Mechanism of Increased BK Channel Activation from a Channel Mutation that Causes Epilepsy
Concerted depolarization and Ca(2+) rise during neuronal action potentials activate large-conductance Ca(2+)- and voltage-dependent K(+) (BK) channels, whose robust K(+) currents increase the rate of action potential repolarization. Gain-of-function BK channels in mouse knockout of the inhibitory β4...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2654085/ https://ncbi.nlm.nih.gov/pubmed/19204188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200810141 |
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