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Identification of ENA1 as a Virulence Gene of the Human Pathogenic Fungus Cryptococcus neoformans through Signature-Tagged Insertional Mutagenesis

A library of more than 4,500 signature-tagged insertion mutants of the human pathogenic fungus Cryptococcus neoformans was generated, and a subset was screened in a murine inhalation model to identify genes required for virulence. New genes that regulate aspects of C. neoformans virulence were also...

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Main Authors: Idnurm, Alexander, Walton, Felicia J., Floyd, Anna, Reedy, Jennifer L., Heitman, Joseph
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology (ASM) 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653249/
https://ncbi.nlm.nih.gov/pubmed/19151325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00375-08
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