Hepatotoxicity and Gastrointestinal Intolerance when Healthy Volunteers taking Rifampin add Twice-Daily Atazanavir and Ritonavir

BACKGROUND: Rifampin is the cornerstone of antituberculosis therapy, but induction of hepatic cytochrome P450 (CYP) 3A by rifampin markedly lowers HIV protease inhibitor plasma concentrations. METHODS: This phase I, open-label, one-arm study was designed to assess pharmacokinetic interactions and sa...

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Main Authors: Haas, David W., Koletar, Susan L., Laughlin, Laura, Kendall, Michelle A., Suckow, Carol, Gerber, John G., Zolopa, Andrew R., Bertz, Richard, Child, Michael J., Hosey, Lara, Alston-Smith, Beverly, Acosta, Edward P.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653210/
https://ncbi.nlm.nih.gov/pubmed/19194314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e318189a7df
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