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Hepatotoxicity and Gastrointestinal Intolerance when Healthy Volunteers taking Rifampin add Twice-Daily Atazanavir and Ritonavir
BACKGROUND: Rifampin is the cornerstone of antituberculosis therapy, but induction of hepatic cytochrome P450 (CYP) 3A by rifampin markedly lowers HIV protease inhibitor plasma concentrations. METHODS: This phase I, open-label, one-arm study was designed to assess pharmacokinetic interactions and sa...
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Main Authors: | , , , , , , , , , , , |
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Format: | Artigo |
Language: | Inglês |
Published: |
2009
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Subjects: | |
Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2653210/ https://ncbi.nlm.nih.gov/pubmed/19194314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e318189a7df |
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