Persistent antigenic stimulation alters the transcription program in T cells, resulting in antigen-specific tolerance

Repetitive antigen stimulation induces peripheral T cell tolerance in vivo. It is not known, however, whether multiple stimulations merely suppress T cell activation or, alternatively, change the transcriptional program to a distinct, tolerant state. In this study, we have discovered that STAT3 and...

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Bibliographische Detailangaben
Hauptverfasser: Anderson, Per O., Manzo, Barbara A., Sundstedt, Anette, Minaee, Sophie, Symonds, Alistair, Khalid, Sabah, Rodriguez-Cabezas, Maria E., Nicolson, Kirsty, Li, Suling, Wraith, David C., Wang, Ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652694/
https://ncbi.nlm.nih.gov/pubmed/16708405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200635883
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