N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking

Huntington's disease (HD) is caused by polyglutamine (polyQ) expansion in huntingtin (htt), a large (350 kDa) protein that localizes predominantly to the cytoplasm. Proteolytic cleavage of mutant htt yields polyQ-containing N-terminal fragments that are prone to misfolding and aggregation. Dise...

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Main Authors: Orr, Adam L., Li, Shihua, Wang, Chuan-En, Li, He, Wang, Jianjun, Rong, Juan, Xu, Xingshun, Mastroberardino, Pier Giorgio, Greenamyre, J. Timothy, Li, Xiao-Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652473/
https://ncbi.nlm.nih.gov/pubmed/18337408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0106-08.2008
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