Pediatric Phase I and Pharmacokinetic Study of Erlotinib Followed by the Combination of Erlotinib and Temozolomide: A Children's Oncology Group Phase I Consortium Study

PURPOSE: We conducted a phase I and pharmacokinetic study of the epidermal growth factor receptor (EGFR) inhibitor erlotinib as a single agent and in combination with temozolomide in children with refractory solid tumors. PATIENTS AND METHODS: Erlotinib was administered orally once daily to cohorts...

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Detalhes bibliográficos
Main Authors: Jakacki, Regina I., Hamilton, Marta, Gilbertson, Richard J., Blaney, Susan M., Tersak, Jean, Krailo, Mark D., Ingle, Ashish M., Voss, Stephan D., Dancey, Janet E., Adamson, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2008
Assuntos:
Pediatric Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652086/
https://ncbi.nlm.nih.gov/pubmed/18794549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2007.15.2306
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