Pediatric Phase I Trial and Pharmacokinetic Study of Dasatinib: A Report From the Children's Oncology Group Phase I Consortium

PURPOSE: Dasatinib is an orally available tyrosine kinase inhibitor with low nanomolar activity against SRC family kinases, BCR-ABL, c-KIT, EPHA2, and the PDGF-β receptor. Dasatinib was found to have selective activity in several tumor models in the Pediatric Preclinical Testing Program. PATIENTS AN...

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Detalhes bibliográficos
Main Authors: Aplenc, Richard, Blaney, Susan M., Strauss, Lewis C., Balis, Frank M., Shusterman, Suzanne, Ingle, Ashish Mark, Agrawal, Shruti, Sun, Junfeng, Wright, John J., Adamson, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2011
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068059/
https://ncbi.nlm.nih.gov/pubmed/21263099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.30.7231
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