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hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress
Genotoxic stress activates the phosphatidylinositol 3-kinase like kinases (PIKKs) that phosphorylate proteins involved in cell cycle arrest, DNA repair, and apoptosis. Previous work showed that the PIKK ataxia telangiectasia mutated (ATM) but not ATR (ATM and Rad3-related) phosphorylates p53 (Ser15)...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2651885/ https://ncbi.nlm.nih.gov/pubmed/18332866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.48 |
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