A Simple Mathematical Model of Signaling Resulting from the Binding of Lipopolysaccharide with Toll-like Receptor 4 Demonstrates Inherent Preconditioning Behavior

The complex biology of Gram-negative bacterial lipopolysaccharide (LPS) is central to the acute inflammatory response in sepsis and related diseases. Repeated treatment with LPS can lead to desensitization or enhancement of subsequent responses both in vitro and in vivo (a phenomenon known as precon...

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Bibliographic Details
Main Authors: Rivière, Beatrice, Epshteyn, Yekaterina, Swigon, David, Vodovotz, Yoram
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651675/
https://ncbi.nlm.nih.gov/pubmed/18950647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mbs.2008.10.002
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