Transgenic rescue of ataxia mice reveals a male-specific sterility defect

Homozygous ataxia (ax(J)) mice have reduced expression of ubiquitin-specific protease 14 (Usp14), resulting in severe neuromuscular defects and death by 2 months of age. Transgenic expression of Usp14 exclusively in the nervous system of ax(J) mice (ax(J)-Tg) prevents early lethality and restores mo...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Crimmins, Stephen, Sutovsky, Miriam, Chung, Ping-Chen, Huffman, Alexis, Wheeler, Crystal, Swing, Deborah A., Roth, Kevin, Wilson, Julie, Sutovsky, Peter, Wilson, Scott
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651617/
https://ncbi.nlm.nih.gov/pubmed/18926813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2008.09.021
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