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Transgenic rescue of ataxia mice reveals a male-specific sterility defect
Homozygous ataxia (ax(J)) mice have reduced expression of ubiquitin-specific protease 14 (Usp14), resulting in severe neuromuscular defects and death by 2 months of age. Transgenic expression of Usp14 exclusively in the nervous system of ax(J) mice (ax(J)-Tg) prevents early lethality and restores mo...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2651617/ https://ncbi.nlm.nih.gov/pubmed/18926813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2008.09.021 |
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