Genetic Variation in ATP5O Is Associated with Skeletal Muscle ATP50 mRNA Expression and Glucose Uptake in Young Twins

BACKGROUND: Impaired oxidative capacity of skeletal muscle mitochondria contribute to insulin resistance and type 2 diabetes (T2D). Furthermore, mRNA expression of genes involved in oxidative phosphorylation, including ATP5O, is reduced in skeletal muscle from T2D patients. Our aims were to investig...

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Главные авторы: Rönn, Tina, Poulsen, Pernille, Tuomi, Tiinamaija, Isomaa, Bo, Groop, Leif, Vaag, Allan, Ling, Charlotte
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2009
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651471/
https://ncbi.nlm.nih.gov/pubmed/19274082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004793
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