Cyclin A–Cdk1 regulates the origin firing program in mammalian cells

Somatic mammalian cells possess well-established S-phase programs with specific regions of the genome replicated at precise times. The ATR–Chk1 pathway plays a central role in these programs, but the mechanism for how Chk1 regulates origin firing remains unknown. We demonstrate here the essential ro...

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Autors principals: Katsuno, Yuko, Suzuki, Ayumi, Sugimura, Kazuto, Okumura, Katsuzumi, Zineldeen, Doaa H., Shimada, Midori, Niida, Hiroyuki, Mizuno, Takeshi, Hanaoka, Fumio, Nakanishi, Makoto
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651338/
https://ncbi.nlm.nih.gov/pubmed/19221029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809350106
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