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Persistent elimination of ErbB-2/HER2-overexpressing tumors using combinations of monoclonal antibodies: Relevance of receptor endocytosis

Monoclonal antibodies (mAbs) to ErbB-2/HER2 or to its sibling, the epidermal growth factor receptor (EGFR), prolong survival of cancer patients, especially when combined with cytotoxic therapies. However, low effectiveness of therapeutic mAbs and the evolution of patient resistance call for improvem...

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Autores principales: Ben-Kasus, Tsipi, Schechter, Bilha, Lavi, Sara, Yarden, Yosef, Sela, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651295/
https://ncbi.nlm.nih.gov/pubmed/19218427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812059106
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