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Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan
Alterations in cellular cholesterol synthesis or content in cultured neurons affect the cleavage of amyloid precursor protein to amyloidogenic Aβ(40) and Aβ(42) peptides characteristic of Alzheimer's disease. To determine whether a decrease in cholesterol synthesis affects amyloid precursor pro...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2009
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2651246/ https://ncbi.nlm.nih.gov/pubmed/19204288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813349106 |
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