High-affinity neurotrophin receptors and ligands promote leukemogenesis

Neurotrophins (NTs) and their receptors play a key role in neurogenesis and survival. The TRK (tropomyosin-related kinase) receptor protein tyrosine kinases (TRKA, TRKB, TRKC) are high-affinity NT receptors that are expressed in a variety of human tissues. Their role in normal and malignant hematopo...

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Autori principali: Li, Zhixiong, Beutel, Gernot, Rhein, Mathias, Meyer, Johann, Koenecke, Christian, Neumann, Thomas, Yang, Min, Krauter, Jürgen, von Neuhoff, Nils, Heuser, Michael, Diedrich, Helmut, Göhring, Gudrun, Wilkens, Ludwig, Schlegelberger, Brigitte, Ganser, Arnold, Baum, Christopher
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2009
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651014/
https://ncbi.nlm.nih.gov/pubmed/19059881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-05-155200
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