Residual DNA methylation at remission is prognostic in adult Philadelphia chromosome–negative acute lymphocytic leukemia

Pretreatment aberrant DNA methylation patterns are stable at time of relapse in acute lymphocytic leukemia (ALL). We hypothesized that the detection of residual methylation alterations at the time of morphologic remission may predict for worse prognosis. We developed a real-time bisulfite polymerase...

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Detalhes bibliográficos
Main Authors: Yang, Hui, Kadia, Tapan, Xiao, Lianchun, Bueso-Ramos, Carlos E., Hoshino, Koyu, Thomas, Deborah Ann, O'Brien, Susan, Jabbour, Elias, Pierce, Sherry, Rosner, Gary L., Kantarjian, Hagop M., Garcia-Manero, Guillermo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651008/
https://ncbi.nlm.nih.gov/pubmed/19109226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-141002
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