Blood Stage Malaria Vaccine Eliciting High Antigen-Specific Antibody Concentrations Confers No Protection to Young Children in Western Kenya

OBJECTIVE: The antigen, falciparum malaria protein 1 (FMP1), represents the 42-kDa C-terminal fragment of merozoite surface protein-1 (MSP-1) of the 3D7 clone of P. falciparum. Formulated with AS02 (a proprietary Adjuvant System), it constitutes the FMP1/AS02 candidate malaria vaccine. We evaluated...

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Main Authors: Ogutu, Bernhards R., Apollo, Odika J., McKinney, Denise, Okoth, Willis, Siangla, Joram, Dubovsky, Filip, Tucker, Kathryn, Waitumbi, John N., Diggs, Carter, Wittes, Janet, Malkin, Elissa, Leach, Amanda, Soisson, Lorraine A., Milman, Jessica B., Otieno, Lucas, Holland, Carolyn A., Polhemus, Mark, Remich, Shon A., Ockenhouse, Christian F., Cohen, Joe, Ballou, W. Ripley, Martin, Samuel K., Angov, Evelina, Stewart, V. Ann, Lyon, Jeffrey A., Heppner, D. Gray, Withers, Mark R.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2009
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Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650803/
https://ncbi.nlm.nih.gov/pubmed/19262754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004708
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