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Safety and Reactogenicity of an MSP-1 Malaria Vaccine Candidate: A Randomized Phase Ib Dose-Escalation Trial in Kenyan Children

OBJECTIVE: Our aim was to evaluate the safety, reactogenicity, and immunogenicity of an investigational malaria vaccine. DESIGN: This was an age-stratified phase Ib, double-blind, randomized, controlled, dose-escalation trial. Children were recruited into one of three cohorts (dosage groups) and ran...

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Detalhes bibliográficos
Main Authors: Withers, Mark R, McKinney, Denise, Ogutu, Bernhards R, Waitumbi, John N, Milman, Jessica B, Apollo, Odika J, Allen, Otieno G, Tucker, Kathryn, Soisson, Lorraine A, Diggs, Carter, Leach, Amanda, Wittes, Janet, Dubovsky, Filip, Stewart, V. Ann, Remich, Shon A, Cohen, Joe, Ballou, W. Ripley, Holland, Carolyn A, Lyon, Jeffrey A, Angov, Evelina, Stoute, José A, Martin, Samuel K, Heppner, D. Gray
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851726/
https://ncbi.nlm.nih.gov/pubmed/17124529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pctr.0010032
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