Glutamine Deprivation Induces Abortive S-Phase Rescued by Deoxyribonucleotides in K-Ras Transformed Fibroblasts

BACKGROUND: Oncogene activation plays a role in metabolic reprogramming of cancer cells. We have previously shown that K-ras transformed fibroblasts have a stronger dependence on glycolysis and a reduced oxidative phosphorylation ability as compared to their normal counterparts. Another metabolic ad...

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Autores principales: Gaglio, Daniela, Soldati, Chiara, Vanoni, Marco, Alberghina, Lilia, Chiaradonna, Ferdinando
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650790/
https://ncbi.nlm.nih.gov/pubmed/19262748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004715
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