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Acid-degradable polyurethane particles for protein-based vaccines: biological evaluation and in vitro analysis of particle degradation products

Acid-degradable particles containing a model protein antigen, ovalbumin, were prepared from a polyurethane with acetal moieties embedded throughout the polymer, and characterized by dynamic light scattering and transmission electron microscopy. The small molecule degradation by-product of the partic...

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Autors principals: Bachelder, Eric M., Beaudette, Tristan T., Broaders, Kyle E., Paramonov, Sergey E., Dashe, Jesse, Fréchet, Jean M. J.
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650432/
https://ncbi.nlm.nih.gov/pubmed/18710254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp800068x
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