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Quantifying Global Tolerance of Biochemical Systems: Design Implications for Moiety-Transfer Cycles

Robustness of organisms is widely observed although difficult to precisely characterize. Performance can remain nearly constant within some neighborhood of the normal operating regime, leading to homeostasis, but then abruptly break down with pathological consequences beyond this neighborhood. Curre...

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Autors principals: Coelho, Pedro M. B. M., Salvador, Armindo, Savageau, Michael A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650413/
https://ncbi.nlm.nih.gov/pubmed/19300483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000319
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