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Quantifying global tolerance of biochemical systems: design implications for moiety-transfer cycles.

Robustness of organisms is widely observed although difficult to precisely characterize. Performance can remain nearly constant within some neighborhood of the normal operating regime, leading to homeostasis, but then abruptly break down with pathological consequences beyond this neighborhood. Curre...

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Detalhes bibliográficos
Main Authors: Pedro M B M Coelho, Armindo Salvador, Michael A Savageau
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2009-03-01
Colecção:PLoS Computational Biology
Acesso em linha:http://europepmc.org/articles/PMC2650413?pdf=render
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