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Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice

The MHC class I-related receptor FcRn regulates the levels and persistence of IgG in vivo. This receptor salvages IgG from lysosomal degradation within cells, and the binding properties of an IgG for FcRn correlate with in vivo half-life. FcRn is expressed at multiple different sites throughout adul...

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Bibliografiske detaljer
Main Authors: Montoyo, Héctor Pérez, Vaccaro, Carlos, Hafner, Martin, Ober, Raimund J., Mueller, Werner, Ward, E. Sally
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650344/
https://ncbi.nlm.nih.gov/pubmed/19188594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810796106
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