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Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice
The MHC class I-related receptor FcRn regulates the levels and persistence of IgG in vivo. This receptor salvages IgG from lysosomal degradation within cells, and the binding properties of an IgG for FcRn correlate with in vivo half-life. FcRn is expressed at multiple different sites throughout adul...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2650344/ https://ncbi.nlm.nih.gov/pubmed/19188594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810796106 |
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