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Urea, but not guanidinium, destabilizes proteins by forming hydrogen bonds to the peptide group
The mechanism by which urea and guanidinium destabilize protein structure is controversial. We tested the possibility that these denaturants form hydrogen bonds with peptide groups by measuring their ability to block acid- and base-catalyzed peptide hydrogen exchange. The peptide hydrogen bonding fo...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2650309/ https://ncbi.nlm.nih.gov/pubmed/19196963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812588106 |
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