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Neurosteroids in the context of stress: Implications for depressive disorders

Animal models indicate that the neuroactive steroids 3α,5α-THP (allopregnanolone) and 3α,5α-THDOC (allotetrahydroDOC) are stress responsive, serving as homeostatic mechanisms in restoring normal GABAergic and hypothalamic-pituitary-adrenal (HPA) function following stress. While neurosteroid increase...

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Detalhes bibliográficos
Main Authors: Girdler, Susan S., Klatzkin, Rebecca
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650267/
https://ncbi.nlm.nih.gov/pubmed/17597217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2007.05.006
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