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Identifying Critical Non-Catalytic Residues that Modulate Protein Kinase A Activity

BACKGROUND: Distal interactions between discrete elements of an enzyme are critical for communication and ultimately for regulation. However, identifying the components of such interactions has remained elusive due to the delicate nature of these contacts. Protein kinases are a prime example of an e...

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Autori principali: Kennedy, Eileen J., Yang, Jie, Pillus, Lorraine, Taylor, Susan S., Ghosh, Gourisankar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650257/
https://ncbi.nlm.nih.gov/pubmed/19270744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004746
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