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β(2)-Adrenoceptor signaling is required for the development of an asthma phenotype in a murine model

Chronic regular use of β(2)-adrenoceptor (β(2)-AR) agonists in asthma is associated with a loss of disease control and increased risk of death. Conversely, we have found that administration of β(2)-AR inverse agonists results in attenuation of the asthma phenotype in an allergen-driven murine model....

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Detalhes bibliográficos
Main Authors: Nguyen, Long P., Lin, Rui, Parra, Sergio, Omoluabi, Ozozoma, Hanania, Nicola A., Tuvim, Michael J., Knoll, Brian J., Dickey, Burton F., Bond, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650174/
https://ncbi.nlm.nih.gov/pubmed/19171883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810902106
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