R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/β-catenin pathway

R-Spondin1 (RSpo1) is a novel secreted protein that augments canonical Wnt/β-catenin signaling. We injected recombinant RSpo1 protein into transgenic Wnt reporter TOPGAL mice and have identified the oral mucosa as a target tissue for RSpo1. Administration of RSpo1 into normal mice triggered nuclear...

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Main Authors: Zhao, Jingsong, Kim, Kyung-Ah, De Vera, Josephine, Palencia, Servando, Wagle, Marie, Abo, Arie
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650156/
https://ncbi.nlm.nih.gov/pubmed/19179402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805159106
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