The Epstein–Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species

The Epstein–Barr virus (EBV) nuclear antigen (EBNA)-1 is the only viral protein expressed in all EBV-carrying malignancies, but its contribution to oncogenesis has remained enigmatic. We show that EBNA-1 induces chromosomal aberrations, DNA double-strand breaks, and engagement of the DNA damage resp...

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Bibliografiska uppgifter
Huvudupphovsmän: Gruhne, Bettina, Sompallae, Ramakrishna, Marescotti, Diego, Kamranvar, Siamak Akbari, Gastaldello, Stefano, Masucci, Maria G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2009
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650153/
https://ncbi.nlm.nih.gov/pubmed/19139406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810619106
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