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The Epstein–Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species
The Epstein–Barr virus (EBV) nuclear antigen (EBNA)-1 is the only viral protein expressed in all EBV-carrying malignancies, but its contribution to oncogenesis has remained enigmatic. We show that EBNA-1 induces chromosomal aberrations, DNA double-strand breaks, and engagement of the DNA damage resp...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2650153/ https://ncbi.nlm.nih.gov/pubmed/19139406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810619106 |
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